See RNAi in action with Nature Genetics’ animation and slideshow.
mRNA archive.
Hints and tips from Nature Application Notes: Stellaris™ fluorescence in situ hybridization (FISH) probes: a powerful tool for mRNA detection
From Genetic Engineering & Biotechnology News – a review of Roche’s kit to facilitate fast, reproducible gene-expression data.
Ovarian cancer is the second most common gynaecological cancer, and is often diagnosed late, as its symptoms overlap with many other conditions. It causes around 70% of the deaths associated with ovarian cancer in the USA. The Cancer Genome Atlas (TGCA) Research Network has published its integrated genomic analysis of ovarian carcinoma – this is the second cancer completed by this group.
Even DNA has to know where to stop. Messenger RNA uses translation termination codons, also known as nonsense codons, to signal the end of coding for a protein, and mutations can lead to incomplete proteins. These may be behind genetic disease. Researchers have found a way to turn the nonsense into sense, suppressing early termination.
MicroRNAs (miRNAs) are short strands of RNA. They are around 22 nucleotides long and bind to messenger RNA (mRNA), regulating gene expression, often through silencing or repression. Their misregulation has been implicated in disease, and now it appears that they may also be involved in evolution.
Even though RNA interference (RNAi) was the subject of the prestigious Nobel Prize in Physiology or Medicine in 2006, therapeutics based on this technology have been slow to move into clinical trials because of problems with getting the short strands of RNA inside the cells.
So what does RNAi actually do? …
